Description
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Historical Background and Scientific Context Scientific interest in peptide-mediated biological regulation expanded considerably during the late twentieth century as advances in molecular biology enabled researchers to identify increasingly complex signalling systems
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They developed a PAMAM dendrimer whose terminal groups were modified to obtain a cysteamine-like structure (PAMAM-DEN CYS ) and demonstrated its efficacy in reducing PA infection and growth, along with its ability to rescue the misfolded F508del-CFTR from aggresome-bodies by inducing its trafficking to the plasma membrane
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