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Glutamatergic dysfunction impacts disease severity [31], with higher levels of glutamate mostly in the anterior cingulate cortex and prefrontal cortex, as shown in magnetic resonance spectroscopy ( 1 H-MRS) studies [32]
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Interestingly, the combination treatment of ES2 plus Dabrafenib resulted in a greater than 65% increased survival time with 50% of mice surviving twice as long as untreated mice (p=0.048) (Fig