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However, we found that substitution of the amino group by chloro was tolerated, as the corresponding analog 46 exhibited an IC 50 value of 0.01 ยตM
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Similarly, trypanosomes utilize a highly specialized peroxisome, labeled as glycosome, for important metabolic functions, including glycolytic pathway, pentose-phosphate pathway, ฮฒ-oxidation of fatty acids, purine salvage, and biosynthetic pathways for pyrimidines, ether-lipids and squalenes (Haanstra et al., 2016)