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Commenters cited two peer-reviewed studies that found no demonstrated clinical benefit of using ultrasound guidance for superficial radiation treatment, [68] and stated that ultrasound is not medically necessary for the treatment of superficial skin cancers and is widely considered low-value care
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6.3 Epigenetic Reprogramming Strategy Given NNMT’s role in the epigenetic architecture of tumor stroma, targeting it may help overcome therapy resistance—specifically in cancers where tumor angiogenesis and fibrosis are driven by NNMT‑expressing fibroblasts