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In addition, BHB inhibits NLRP3 activation, resulting in a reduced release of inflammatory factors, particularly IL-1β and IL-18, by inhibiting caspase-1 activation (21)
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There exist some studies on Nrf2, a key factor of oxidative stress, but on the one hand, Nrf2 has preventive oxidative and anti-inflammatory effects on normal cells, on the other hand, it can promote tumor metastasis and induce drug resistance [250, 251]
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