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Since then, the incidence of pregnancies and live births among patients undergoing ovarian tissue cryopreservation and transplantation has increased significantly ( It is well documented that the processes of cryopreservation and transplantation induce significant oxidative stress in ovarian tissue, a phenomenon closely paralleling the impact of ROS observed in cryopreserved oocytes ( Mechanistically, oxidative stress triggers endoplasmic reticulum stress through the activation of the PERK-eIF2α-ATF4 and IRE1α-XBP1 signaling pathways, as well as through the upregulation of CHOP (C/EBP homologous protein), which promotes apoptotic signaling ( Figure 4
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Astragaloside IV alleviates Schwann cell injury in diabetic peripheral neuropathy by regulating microRNA-155-mediated autophagy