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For CKD Patients, B12 Supplementation May Be Helpful - MPR
Renal Effects In the kidney, prostaglandins, produced by both COX-1 and COX-2, are important regulators of sodium and water reabsorption through PGE2 and of renal function and hemodynamics via PGI2 in response to vasoconstrictive factors (e.g., endothelin-1, a factor that increases peripheral vascular resistance) and through effects on the renin-angiotensin system
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Recent investigations (Kwon et al.) have identified AOD 9604 as a chondroprotective agent