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However, analysis of SNPs has shown that patients with a specific genotype ( TOLLIP rs3750920) have a better response to NAC compared with the general IPF population
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In summary, we here identify a previously unrecognized ANKIB1–K11-Ub–OPTN–TBK1 signalling axis as the crucial driver of IRF3-mediated IFN induction downstream of TLR3, TLR4 and cGAS–STING (Extended Data Fig